Regenerative
Polynucleotides (PDRN)
Deep skin regeneration. Long-term improvement.
Biostimulating injections using purified polynucleotides to support skin quality and hydration at a cellular level. A course of treatments is typically recommended.
At a glance
Quick facts
- Category
- Regenerative
- Appointment duration
- 30 – 45 min
- Anaesthesia
- Topical anaesthetic cream available
- Downtime
- 24 – 48 hrs
- Results onset
- Discussed during consultation
- Longevity
- Discussed during consultation
- Sessions
- Discussed during consultation
- Follow-up
- Ongoing course; reviewed at each session
About this treatment
Overview
Polynucleotides (PDRN) are injectable biostimulators derived from purified salmon or trout DNA fragments, chosen for their structural similarity to human DNA. They work by supporting cellular regeneration and promoting the production of collagen and other extracellular matrix components at a deep skin level.
Unlike volumising treatments, polynucleotides do not add structure or change the shape of the face. Their role is to improve the quality of the skin itself — addressing concerns such as fine texture, crepiness, dehydration, and skin dullness from within.
A course of sessions is typically recommended to achieve and sustain results. The treatment can be used on the face, neck, décolletage, under-eyes, and scalp, and is often used alongside other treatments as part of a combined skin health plan.
Concerns this treatment may address
Individual suitability for addressing any specific concern is determined at consultation.
What it may offer
Potential benefits
The following describes potential benefits. Individual results vary and no outcome can be guaranteed.
May improve skin quality, texture, and overall hydration at a cellular level
Can support collagen and elastin production over a course of treatment
May reduce the appearance of fine lines associated with skin quality rather than muscle movement
Suitable for delicate treatment areas such as the under-eye region and neck
Generally well tolerated across a range of skin types and tones
Can be used on the scalp to support hair follicle health, depending on assessment
Who may be suitable
Adults concerned with skin quality, texture, fine lines, or dehydration
Those seeking a regenerative approach that works gradually over time
Individuals with crepey skin in areas such as the under-eyes, neck, or décolletage
People exploring hair thinning or scalp health improvement, depending on assessment
Those who prefer biostimulatory treatments that do not add volume or change facial shape
Suitability is confirmed at consultation — this list is for general guidance only.
Who may not be suitable
The following are general contraindications. A full medical history review at consultation determines individual suitability.
Individuals who are pregnant or breastfeeding
Those with known allergy to fish or fish products — salmon or trout DNA is used in most formulations
People with active skin infection or inflammation at the proposed treatment site
Individuals with certain autoimmune conditions — reviewed at consultation
Those with a history of keloid scarring, where injectable treatments require careful assessment
Consultation and assessment
Full medical and allergy history, including fish allergy — essential given the product's origin
Assessment of skin quality, concerns, and treatment goals
Discussion of the course of treatment required and realistic expectations
Explanation of the mechanism, procedure, and potential side effects
Skin tone and type assessment to confirm suitability
Written informed consent before any treatment proceeds
The procedure
How it works
The treatment area is cleansed and, where appropriate, a topical anaesthetic may be applied
The polynucleotide solution is injected into the skin using a fine needle or cannula, typically using a serial puncture technique
The product is distributed across the target area at a controlled depth within the dermis
Once in position, the polynucleotides interact with cells in the surrounding tissue to support natural regenerative processes
Over subsequent weeks, improvements in skin quality gradually develop as cellular activity responds to treatment
Sessions are typically spaced a few weeks apart as part of a structured course
Preparation
Confirm any fish or seafood allergies with the practitioner before booking
Avoid alcohol for 24 hours before treatment
Avoid blood-thinning supplements if advised by the practitioner and safe to do so
Arrive with clean skin free of makeup
Inform the practitioner of any recent illness or new medications
During treatment
Sessions typically last between 30 and 45 minutes
A topical anaesthetic cream may be applied for comfort before treatment begins
Multiple small injections are placed across the treatment area — this can be uncomfortable in some areas
Mild stinging, pressure, or an itching sensation during injection is common and expected
You can return to most daily activities following the appointment
Aftercare
Following aftercare instructions carefully supports your recovery and helps protect your results. Contact the clinic if you have any concerns.
Avoid touching or rubbing the treated area for several hours after treatment
Some redness and small raised injection marks are normal and typically resolve within hours to a day or two
Avoid strenuous exercise, saunas, and excessive heat for 24 hours
Use gentle skincare products and avoid active ingredients such as retinoids or acids in the immediate days following treatment
Apply broad-spectrum SPF daily — this is essential throughout and after any treatment course
Attend all scheduled sessions in the course as planned for the best potential outcomes
Recovery timeline
Timelines are approximate. Individual recovery varies.
- Immediately after
Small raised injection marks, redness, and mild swelling are normal and expected. These typically resolve within a few hours.
- Days 1–3
Any residual swelling and redness should be resolving. The skin may feel slightly firm at injection sites.
- Weeks 2–6
Gradual improvements in skin quality may begin to become apparent as cellular processes respond to treatment.
- After a course
The full potential benefit of the treatment is typically more visible after a structured course of sessions rather than a single treatment.
What to expect
Results vary between individuals. No specific outcome can be guaranteed. The following is general guidance only — your practitioner will discuss what is realistic for your individual situation.
Results are gradual and typically become more apparent over several weeks and across a course of sessions
Individual response to biostimulatory treatments varies — no specific outcome can be guaranteed
Improvements may include enhanced skin hydration, texture refinement, and a reduction in the appearance of fine skin lines
Maintenance sessions may be beneficial once a course is complete — discussed at review
Polynucleotides support skin quality from within; they do not restructure or volumise the face
Safety information
Risks and side effects
Common
- Redness, swelling, and small raised bumps at injection sites — typically resolve within hours to days
- Mild bruising
- Temporary tenderness or sensitivity in the treated area
Less common
- Prolonged swelling or firmness at injection sites
- Itching in the treated area
- Small visible papules that resolve over days to weeks
Rare
- Allergic reaction — particularly relevant for individuals with fish allergies
- Infection at injection sites
- Granuloma formation — a delayed inflammatory response that is manageable if it occurs
If you experience severe pain, swelling, skin colour changes, vision changes, or any symptoms that concern you after treatment, contact the clinic immediately or seek emergency medical care.
This is not an exhaustive list. All risks are discussed fully at your consultation before any treatment proceeds. This treatment is never described as risk-free.
Questions
Frequently asked questions
Explore further
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Begin your journey
Begin with a consultation designed around you.
Every treatment begins with an unhurried clinical conversation. No pressure, no obligation — just an honest, individualised assessment.
Medical disclaimer: This page is for educational purposes only and does not constitute medical advice. All treatments carry risks that are discussed in full at a clinical consultation. Individual results vary and no specific outcome is guaranteed. A consultation with a qualified practitioner is required to confirm suitability before any treatment proceeds.